Correction: Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT
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چکیده
Correction: Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT Baerbel Keller, Irina Zaidman, O. Sascha Yousefi, Dov Hershkovitz, Jerry Stein, Susanne Unger, Kristina Schachtrup, Mikael Sigvardsson, Amir A. Kuperman, Avraham Shaag, Wolfgang W. Schamel, Orly Elpeleg, Klaus Warnatz, and Polina Stepensky Vol. 213, No. 7, June 27, 2016. https://doi.org/10.1084/jem.20151110
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Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT
The adapter protein linker for activation of T cells (LAT) is a critical signaling hub connecting T cell antigen receptor triggering to downstream T cell responses. In this study, we describe the first kindred with defective LAT signaling caused by a homozygous mutation in exon 5, leading to a premature stop codon deleting most of the cytoplasmic tail of LAT, including the critical tyrosine res...
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